In this issue of Developmental Cell, Chuyen et al. (2021) suggest that the Scf/Kit pathway controls mutual repulsion of multiciliated cells and their affinity for epidermal cell junctions through soluble and membrane-associated Scf ligands, respectively. In a comment published in the same issue, Michel Milinkovitch discusses the possibility that effective self-organisational patterning emerges at the mesoscopic scale as a small set of effective behaviours. Hence, he conjectures that a relatively simple, coherent and predictive theory of development at the mesoscopic and macroscopic scales can emerge from the unmanageable profusion of variables that populate the nanoscopic and microscopic scales.
Emergence of self-organisational patterning at the mesoscopic scale
Michel C. Milinkovitch
Developmental Cell, 56, March 22, 2021